Rheumatoid arthritis
Conditions
Interventions
After obtaining written consent from the study participants, the investigational drug indocyanine green will be administered intravenously within 100 days of consent acquisition. The observation sites
Sponsors
Kotani Takuya
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Rheumatoid arthritis patients Patients with rheumatoid arthritis over 18 years of age Patients with typical Heberden's nodes, Bouchard deformities, or osteophyte formation on hand X-rays Patients diagnosed with rheumatoid arthritis based on the 2010 ACR criteria Those who have received sufficient explanation for participating in this study and have obtained written consent of their own free will after sufficient understanding. Osteoarthritis of the hand patients Patients aged 18 and older diagnosed with osteoarthritis of the hand. Patients with typical Heberden's nodes, Bouchard deformities, or osteophyte formation on hand X-rays Those who do not suffer from rheumatoid arthritis Those who have received sufficient explanation for participating in this study and have obtained written consent of their own free will after sufficient understanding. Healthy Individuals Those who are 18 years of age or older Those who do not suffer from rheumatoid arthritis Those who do not suffer from osteoarthritis Those who have received sufficient explanation for participating in this study and have obtained written consent of their own free will after sufficient understanding.
Exclusion criteria
Exclusion criteria: Those who have a history of allergy to ICG. Pregnant or breastfeeding women. Those who have severe cardiovascular or liver disease. Any other patients who are judged to be inappropriate for the study by the principal investigator (co-investigator).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantitative evaluation of synovitis using ICG fluorescence Imaging (including comparison of values in rheumatoid arthritis patients with those in healthy Individuals and osteoarthritis of the hand patients) | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation between the quantitative evaluation values of synovitis using ICG fluorescence imaging and the assessment of affected joints through X-ray and joint inflammation evaluation using ultrasound. Correlation between the quantitative evaluation values of synovitis using ICG fluorescence imaging and the assessment of disease activity in rheumatoid arthritis (DAS28-CRP, DAS28-ESR, CDAI, SDAI) and AD(HAQ). | — |
Contacts
Public ContactTakuya Kotani
Osaka Medical and Pharmaceutical University Hospital
Outcome results
None listed