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Effects of Ripasudil-brimonidine fixed-dose Combination using rho Kinase inhibitor and alpha2 adrenergic receptor agonist on aqueous column in the episcleral vein: a randomized, double-masked crossover clinical trial (ROCK alpha-aqua)

Effects of Ripasudil-brimonidine fixed-dose Combination using rho Kinase inhibitor and alpha2 adrenergic receptor agonist on aqueous column in the episcleral vein: a randomized, double-masked crossover clinical trial (ROCK alpha-aqua) - ROCK alpha-aqua

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs051240091
Enrollment
24
Registered
2024-07-17
Start date
2024-08-02
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health adults

Interventions

Test drugs are GLA-ALPHA combination ophthalmic solution and Ailamide combination opthalmic suspension and Aiphagan opthalmic suspension. One of the test drugs will be instilled in the eye to be ev

Sponsors

Inatani Masaru
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1)Received sufficient explanation for participation and have obtained the subject's free and voluntary written consent. 2)Healthy adults over 18 years old, regardless of gender

Exclusion criteria

Exclusion criteria: 1)Participation in this study is deemed inappropriate by the principal investigator 2)Eye diseases 3)Impossibility observing aqueous veins 4)Pregnant, breastfeeding, may be pregnant, or wish to become pregnant during the research period

Design outcomes

Primary

MeasureTime frame
Aqueous column changes in the episcleral veins 2 hours after instillation of ripasudil versus latanoprost

Secondary

MeasureTime frame
Aqueous column changes in the episcleral veins 8 hours after instillation, intraocular pressure changes (2 and 8 hours after instillation), questionnaire: Score evaluation of usability (eye irritation, blurred vision, conjunctival congestion, bitter taste), adverse events.

Contacts

Public ContactMasaru Inatani

University of Fukui Hospital

inatani@u-fukui.ac.jp+81-776-61-8403

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026