cancer pain cancer pain
Conditions
Interventions
On the day opioid analgesics are started, Lubiprostone is administered orally at a dose of 24 mcg twice daily after breakfast and dinner for 1 week
Sponsors
Kuriyama Toshiyuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. cancer patients over 18 years of age who are involved with the Palliative Care Team and Palliative Care Unit 2. patients who are receiving opioid analgesics (morphine, oxycodone, hydromorphone, tapentadol, fentanyl, tramadol, codeine phosphate) for the first time for cancer pain
Exclusion criteria
Exclusion criteria: 1. patients with diagnosed or suspected intestinal obstruction 2. patients who are unable to take oral intake 3. patients with ECOG PS4 4. patients who have difficulty in obtaining written consent and completing the questionnaire 5. patients with Child-Pugh B or C 6. patients with eGFR less than 30 mL/min/1.73 m2 7. Patients with a history of allergy or contraindication to Lubiprostone 8. patients with diarrhea (Bristol stool scale 6 or 7) 9. patients with a history of irritable bowel syndrome
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of patients diagnosed with opioid-induced constipation (OIC) by ROME IV criteria one week after starting the study | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. change in frequency of spontaneous defecation (/week) during the first week of the study 2. percentage of patients using rescue laxatives during the study period 3. percentage of patients experiencing nausea, vomiting, or diarrhea during the study period 4. other adverse events that may be influenced by the study drug | — |
Contacts
Public ContactToshiyuki Kuriyama
Wakayama Medical University
Outcome results
None listed