Blood cardioplegia versus cold crystalloid cardioplegia: A prospective randomized study

Blood cardioplegia versus cold crystalloid cardioplegia in aortic arch replacement: A prospective randomized study - Blood cardioplegia versus cold crystalloid cardioplegia in aortic arch replacement: A prospective randomized study

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs051220064

Enrollment

Registered

2022-07-22

Start date

2022-09-02

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diseases which require aortic arch replacement

Interventions

We administer blood cardioplegia or crystalloid cardioplegia during cardiac arrest in aortic arch replacement.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients who receive aortic arch replacement 2. More than 20 years old 3. Patients who give written informed consent

Exclusion criteria

Exclusion criteria: 1. Coronary artery stenosis (> 75%) which requires an intervention 2. Preoperative left ventricular systolic dysfunction (EF < 50%) 3. Emergent cases 4. Patients deemed inappropriate by the investigators

Design outcomes

Primary

Measure	Time frame
Left ventricular ejection fraction in thoracic cardioechography 7 days postoperatively	—

Secondary

Measure	Time frame
In-hospital death Overall survival Incidence of low output syndrome Incidence of postoperative myocardial infarction Dosage of cardioplegia CK / CK-MB release Incidence of left ventricular diastolic dysfunction Incidence of right ventricular systolic dysfunction Incidence of ventricular arrhythmia after return to spontaneous rhythm Incidence of new-onset atrial fibrillation 48 hours postoperatively Requirement for implantation of permanent pacemaker Incidence of cerebral stroke Incidence of renal dysfunction Duration of ventilatory support Amount of intraoperative bleeding Amount of intraoperative and postoperative transfusion Re-exploration for bleeding Occurence of diseases, etc.	—

Measure

Time frame

In-hospital death Overall survival Incidence of low output syndrome Incidence of postoperative myocardial infarction Dosage of cardioplegia CK / CK-MB release Incidence of left ventricular diastolic dysfunction Incidence of right ventricular systolic dysfunction Incidence of ventricular arrhythmia after return to spontaneous rhythm Incidence of new-onset atrial fibrillation 48 hours postoperatively Requirement for implantation of permanent pacemaker Incidence of cerebral stroke Incidence of renal dysfunction Duration of ventilatory support Amount of intraoperative bleeding Amount of intraoperative and postoperative transfusion Re-exploration for bleeding Occurence of diseases, etc.

—

Contacts

Public ContactShota Hasegawa

Kobe University Hospital

shotatohs26@gmail.com+81-78-382-5942

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026