Gastric cancer gastric cancer
Conditions
Interventions
Take one packet of Supersynbiotics LBG-P twice a day from 7 days or more before the start of adjuvant chemotherapy to 6 months after the start of adjuvant chemotherapy.
Sponsors
Motoori Masaaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with primary gastric cancer between the ages of 20 and 80 who underwent curative gastr ectomy and scheduled to receive adjuvant chemotherapy with S1 or S1 plus docetaxel 2. PS(ECOG) 0-1 3. White blood cells > lower limit of normal (LLN) or 4000/mm3 and 1500/mm3 5.Hemoglobin>8.0g/dL 6.Aspartate aminotransferase (glutamic-oxaloacetic transaminase) (AST(GOT)) and alanine aminotransferase (glutamic-pyruvic transaminase) (ALT(GPT)) 60 mL/min
Exclusion criteria
Exclusion criteria: 1. Patients with a history of intestinal resection other than gastrectomy, hepatectomy, or pancreatic resection 2. Patients with simultaneous or metachronous cancer 3. Patients with serious postoperative complications 4. Patients with serious comorbidities, such as interstitial pneumonia, pulmonary fibrosis, uncontrolled diabetes, heart failure, renal failure, and liver cirrhosis 5. Patients receiving systemic administration of steroids 6. Patients taking flucytosine 7. Patients taking warfarin potassium
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of patients without dose reduction of S1 or with one-level dose reduction of S1 for one one year | — |
Secondary
| Measure | Time frame |
|---|---|
| Actual total prescription dose / planned total dose ratio of S1 or Docetaxel; Rate of patients without dose reduction of S1 or with one-level dose reduction of S1 for six months; adverse events of chemotherapy; QOL; body composition; muscle strength; nutritional parameter; intestinal environment | — |
Contacts
Public ContactMasaaki Motoori
Osaka General Medical Center
Outcome results
None listed