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Novel gastrointestinal-mediated mechanism of action of metformin

Novel gastrointestinal-mediated mechanism of action of metformin

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs051200115
Enrollment
5
Registered
2021-01-19
Start date
2021-03-08
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients with type 2 diabetes

Interventions

Sponsors

Sakaguchi Kazuhiko
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients with type 2 diabetes 2.Patients taking more than 1000 mg of metformin hydrochloride per day 3.Patients with no obvious lesions in the lower gastrointestinal tract 4.Patients who were 20 years of age or older and Under 75 years old at the time of obtaining consent 5.Patients who have given their voluntary written consent to participate in this clinical study

Exclusion criteria

Exclusion criteria: 1.Patients with contraindications to scopolamine butylbromide 2.Patients suffering from dementia or mental illness 3.Patients with possible bowel perforation or obstruction 4.Patients with metals in the body that are not amenable to PET/MRE testing 5.Pregnant or breast feeding patients 6.Other patients who are deemed inappropriate by the investigators of this clinical study

Design outcomes

Primary

MeasureTime frame
FDG excretion per hour into the intestinal lumen

Secondary

MeasureTime frame
HbA1c, plasma glucose levels and various clinical parameters Presence or absence of disease

Contacts

Public ContactJun Ito

Kobe University Hospital

karen@med.kobe-u.ac.jp+81-78-382-5861

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026