vitiligo vitiligo
Conditions
Interventions
randomized controlled trial
Sponsors
Tsuruta Daisuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients diagnosed with vitiligo 2)Written informed consent by his or her own will 3)20 years old over (Both of male and female) 4)Patients judged by physicians to be poorly effective with standard drugs and phototherapy
Exclusion criteria
Exclusion criteria: 1)Patients treated for new vitiligo from consent to qualification 2)Patients with skin diseases other than vitiligo 3)Patients with food allergy, bronchial asthma, drug allergy 4)Using sumatriptan or mucofilin 5)Patients at risk for gastric bleeding 6)Patients with severe liver damage (fulminant hepatitis, cirrhosis, liver tumor, jaundice that spreads for more than 6 months) 7)Patients with severe renal impairment (nephrotic syndrome, acute renal failure, chronic renal failure, uremia, hydronephrosis) 8)Patients with infectious disease (HBV, HCV, HIV, HTLV-1) 9) Pregnant, possibly pregnant or breast feeding and hope to get pregnant during this study 10)The physicians consider that the patients are inappropriate for this study 11)The patient who smokes at the time of the agreement acquisition and cannot give up smoking during a study period
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Comparison of NAC-administered group and non-NAC-administered group based on 3-grade evaluation of vitiligo image in comparison period (improvement: +1, unchanged: 0, worsening: -1) | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Changes in three-step evaluation of vitiligo images (improved: +1, unchanged: 0, worsened: -1) by continuous administration of NAC during the continuous observation period 2)Quantitative evaluation of vitiligo based on images of vitiligo sites to be evaluated in the comparison period and continuous observation 3)Changes in blood glutathione concentration during the comparison period and the continuous observation period 4)Changes in QOL scores during the comparison period and the continuous observation period | — |
Contacts
Public ContactDaisuke Tsuruta
Osaka Metropolitan University Hosptial
Outcome results
None listed