endometriosis
Conditions
Interventions
Active group: Aglycone isoflavone supplements 2 tablets a day (30 mg / day in terms of aglycone isoflavones) for 4 months
Placebo group: Take placebo 2 tablets a day for 4 months
Sponsors
Taisuke Mori
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: In patients diagnosed with endometriosis, (1) Patients younger than 45 years of age who are 20 years old or older (2) Patients with chronic pelvic pain with a menstrual cycle period of 25 to 38 days and VAS 2.0 or higher
Exclusion criteria
Exclusion criteria: (1) Patients who used dietary supplements containing soy isoflavones within 3 months of their visit (2) Within 3 months from the visit, GnRH analog preparation, endocrine preparation mainly composed of luteinizing hormone or follicular hormone, low-dose pill, medium-dose pill, testosterone derivative and Chinese medicine with indication for endometriosis were used patient (3) Patients who have undergone surgical treatment for endometriosis with transvaginal alcohol fixation, laparotomy, and laparoscope within 3 months after consultation (4) Patients who are pregnant or suspected of being pregnant at the time of consultation (5) Patients who are lactating women at the time of consultation (6) Patients judged by the attending physician as inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain improvement effect before and after administration of aglycone isoflavone. Evaluate menstrual pain, nonmenstrual chronic pelvic pain, sexual intercourse pain, urination and defecation pain by VAS at outpatient visit. | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the size of endometriotic cysts before and after administration of aglycone isoflavones are measured with transvaginal ultrasound. Evaluation of liver function by normal blood sampling. Inquire about the presence or absence of side effects at the visit and continue to confirm safety. | — |
Contacts
Public ContactTakaoka Osamu
University Hospital Kyoto prefectural university of medisine
Outcome results
None listed