Usefulness of l-menthol preparation for endoscopic diagnosis of intestinal metaplasia by Linked Color Imaging

Usefulness of l-menthol preparation for endoscopic diagnosis of intestinal metaplasia by Linked Color Imaging (LCI) - MEDIUM

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs051190115

Enrollment

Registered

2020-03-04

Start date

2020-04-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastrointestinal metaplasia

Interventions

Spray of MINCLEA Spraying Solution

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1 Men and women aged 50 to 80 at the time of consent acquisition (2) A person who, after receiving sufficient explanation for participation in this research, has obtained a consent based on the free will of the research subject person after sufficient understanding

Exclusion criteria

Exclusion criteria: 1) Patients who can not be biopsied while taking basic diseases or antithrombotic drugs, those who have stomach bleeding 2) Person after gastrectomy 3) In addition, those who the research principal doctor judged inappropriate as the research subject

Design outcomes

Primary

Measure	Time frame
Comparison of the rating scale of visibility determined by the three judges.	—

Secondary

Measure	Time frame
1) Comparison of LCI and WLI visibility of the site of intestinal metaplasia before drug spraying 2) Comparison of the LCI range and the WLI range of intestinal metaplasia before drug spraying 3) Comparison of LCI and WLI visibility of the site of intestinal metaplasia after drug spraying 4) Comparison of the LCI range and the WLI range of intestinal metaplasia after drug spraying 5) Comparison of intestinal metaplasia range before and after drug application with LCI 6) Correct diagnosis rate by histopathological diagnosis of intestinal metaplasia (lavender) and non-intestinal metaplasia (non-lavender) diagnosed with LCI 7) Comparison of LCI chromaticity and WLI chromaticity of region of interest (Target Of Interest: LOI) before drug application 8) Comparison of TOI LCI chromaticity and WLI chromaticity after drug application 9) Color comparison of TOI before and after drug application with LCI 10) Comparison of color of TOI before and after drug application with WLI	—

Measure

Time frame

1) Comparison of LCI and WLI visibility of the site of intestinal metaplasia before drug spraying 2) Comparison of the LCI range and the WLI range of intestinal metaplasia before drug spraying 3) Comparison of LCI and WLI visibility of the site of intestinal metaplasia after drug spraying 4) Comparison of the LCI range and the WLI range of intestinal metaplasia after drug spraying 5) Comparison of intestinal metaplasia range before and after drug application with LCI 6) Correct diagnosis rate by histopathological diagnosis of intestinal metaplasia (lavender) and non-intestinal metaplasia (non-lavender) diagnosed with LCI 7) Comparison of LCI chromaticity and WLI chromaticity of region of interest (Target Of Interest: LOI) before drug application 8) Comparison of TOI LCI chromaticity and WLI chromaticity after drug application 9) Color comparison of TOI before and after drug application with LCI 10) Comparison of color of TOI before and after drug application with WLI

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Contacts

Public ContactDemura Mamiko

Hakodate National Hospital

demura.mamiko.ex@mail.hosp.go.jp+81-138-51-6281

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026