Healthy Females
Conditions
Sponsors
Nakagawa Satoshi
Ministry of Education, Culture, Sports, Science and Technology
Fumio Otake
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: For those who meet all of the following criteria. (1) Premenopausal healthy women (2) more than 20 years old and less than 45 years old at the point of informed consent (3) No serious disease under medical treatment A healthy woman is defined as a woman who does not have any abnormality that meets the exclusion criteria and who has had a medical checkup in 2019 or 2020.To determine the eligibility criteria, it is necessary to submit the results of a medical checkup, and following items are confirmed by the docors. Check items: (1) AST and ALT must be below the reference value (2) Serum creatinine is below the reference value (3) The absence of significant edema (4) Systolic blood pressure = Hg10.0g / dl
Exclusion criteria
Exclusion criteria: (1) Pregnant and breastfeeding women (2) History of tretment with oxytocin (3) History of head injury with more than 5minutes consciousness (4) Drug dependence or alcohol dependence or their previous history (5) History of water intoxication with consciousness or seizures (6) Polydipsia (remarkably daily heavy drinking more than 2.5L per day) (7) Renal dysfunction (8) Any other interested person (9)When the research investigator determines inappropriate case for the other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Selection rate of "Personal Performance" or "Tournament Reward" in the economic experiment to measure the competitive preferences after administration of the drug (Oxytocin or Placebo). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.The degree of trusting others calculated based on the "investment " and "return " in the "economic experiment to measure social preference " conducted after administration of the test drug (oxytocin nasal spray or placebo) 2. Oxytocin concentration in saliva collected before administration of the drug (Oxytocin or Placebo) and after the economic experiment to measure competitive preference 3. Testosterone concentration in saliva collected before administration of the drug (Oxytocin or Placebo) and after the economic experiment to measure competitive preference 4. Cortisol concentration in saliva collected before administration of the drug (Oxytocin or Placebo) and after the economic experiment to measure competitive preference 5. The numbers of occurrences and frequency of adverse events during the study period from the time the study subjects were included in this clinical study to that the study was discontinued or terminated 6. Background characteristics such as age, department, behavioral economic characteristics, and impressions of the economic experiments of competitive preference will be surveyed using the questionnaires. | — |
Contacts
Public ContactSatoshi Nakagawa
Osaka University Hospital
Outcome results
None listed