Nocturia due to nocturnal polyuria nocturia, nocturnal polyuria
Conditions
Interventions
Oral administration of desmopressin OD tablet 50 microgram once daily before bedtime
desmopressin
Sponsors
Torimoto Kazumasa
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1 Nocturnal urinary frequency = and >2 and Nocturnal polyuria index (nocturnal urinary volume/24 hours urinary volume) = and >0.33 2 Hours of undisturbed sleep before registration = and 135 mEq/L 4 Creatinine clearance or eGFR (estimate glomerular filtration rate) = and >50 mL/min/1.73m^2
Exclusion criteria
Exclusion criteria: 1 Hyponatremia or the history (Concentration of serum sodium <135 mEq/L) 2 Habitual or Psychogenic polydipsia 3 Heart failure or the history or suspected heart failure 4 Fluid retention that requires diuretic treatment or the history 5 Antidiuretic hormone incompatible secretion syndrome 6 Moderate or severe renal failure (Creatinine clearance or eGFR <50 mL/min/1.73m^2) 7 Hypersensitivity to desmopressin or the history 8 During or scheduled administration of thiazides, thiazide-like diuretics, loop diuretics 9 During or scheduled administration of corticosteroids 10 Carciac pacemaker implantation 11 Judged to be inappropriate by the principal Investigator or subinvestigators
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change of slow wave sleep time (N3 + N4) using a portable electroencephalograph before and after desmopressin administration | — |
Secondary
| Measure | Time frame |
|---|---|
| - Change of Pittsbllrgh Sleep Quality lndex before and after desmopressin administration - Change of nocturnal urinary frequency, the first nocturnal urinary volume, and hours of undisturbed sleep before and after desmopressin administration - Change of sleep time, sleep effiency, sleep quality estimated by VAS before and after desmopressin administration - Correlation between nocturnal urinay frequency and slow wave sleep time (N3 + N4) - Change of delta power from falling asleep to the first urination before and after desmopressin administration | — |
Contacts
Public ContactKazumasa Torimoto
Nara Medical University Hospital
Outcome results
None listed