Randomized study of comparing propylactic antibiotics with enteral nutrition and synbiotics for reducing adverse events during neoadjuvant chemotherapy in patients with esophageal cancer

Randomized study of comparing propylactic antibiotics with enteral nutrition and synbiotics for reducing adverse events during neoadjuvant chemotherapy in patients with esophageal cancer - Randomized study of reducing adverse events during neoadjuvant chemotherapy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs051180153

Enrollment

Registered

2019-03-25

Start date

2016-07-10

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal cancer Esophageal cancer

Interventions

Group A: propylactic antibiotics Group B: enteral nutrition, synbiotics

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients with esophageal cancer scheduled for neoadjuvant chemotherapy

Exclusion criteria

Exclusion criteria: 1. Synchronous or metachronous malignancy 2. Uncontrolled diabetes mellitus

Design outcomes

Primary

Measure	Time frame
Incidence of febrile neutropenia	—

Secondary

Measure	Time frame
Incidence of adverse events, fecal microbiota, fecal organic acid concentration, postoperative complications	—

Contacts

Public ContactKeijiro Sugimura

Osaka International Cancer Institute

sugimura-ke@mc.pref.osaka.jp+81-6-6945-1181

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026