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Cerebral White Matter Stimulation Using Noninvasive Methods

Evaluation of the Safety and Measurability of Cerebral White Matter Stimulation Using Noninvasive Transcranial Magnetic and Ultrasound Stimulation in Healthy Individuals

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs042260032
Enrollment
15
Registered
2026-05-25
Start date
2026-05-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Not applicable, as the participants are healthy volunteers.

Interventions

At the first session, MRI scans for navigation purposes will be acquired. During the second session, the primary motor cortex will first be stimulated using a transcranial magnetic stimulation device
Part B: object naming and verbal fluency tasks
Part C: line bisection test and star cancellation test. Finally, a questionnaire regarding adverse events will be administered.
L01.462.750.245.945.700.500
Non-invasive stimulation, transcranial magnetic stimulation, transcranial ultrasound stimulation

Sponsors

Nakada Mitsutoshi
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Healthy adult volunteers who meet the following criteria Aged 18 to 75 years Not currently receiving treatment with any pharmaceuticals or medical devices No diseases or medical history that meet the exclusion criteria

Exclusion criteria

Exclusion criteria: 1) Individuals who are currently undergoing treatment with oral medications for neuropsychiatric disorders or who have a history of such disorders. 2) Individuals with a history of neurodegenerative diseases, psychiatric disorders, or head trauma. 3) Individuals with a history of seizures (excluding those with a past history, even if they are not currently taking medication). 4) Individuals with claustrophobia. 5) Individuals in socially vulnerable positions, such as those affiliated with the Department of Neurosurgery or enrolled in its programs.

Design outcomes

Primary

MeasureTime frame
Safety, Detectability

Secondary

MeasureTime frame
This includes the completion status of all MRI, transcranial magnetic stimulations, transcranial ultrasound stimulations, brain function tests, and adverse event questionnaires.

Contacts

Public ContactRiho Nakajima

Kanazawa University

nakajima@mhs.mp.kanazawa-u.ac.jp+81-760652628

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026