Tongue cancer Tongue cancer
Conditions
Interventions
This stimulation group: Transcranial direct current electrical stimulation of the primary motor cortex by tDCS will be performed at 1.5 mA for 5 consecutive days for 10 minutes until the discontinuati
Tongue cancer, tDCS
Sponsors
Okamoto Hideki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1 (at the time of first-stage enrollment) 1. Patients with a confirmed diagnosis of tongue cancer (stage II-IVA) and who are eligible for surgery. 2. Age 20-85 years old. 3. General condition: Performance Status (PS) 1-2 (ECOG). 4. Written informed consent for participation in this study has been obtained from the subject or their legal representative. Inclusion Criteria 2 (at the time of second-stage enrollment) 1. Patients with stable general condition and surgical wounds after surgery for stage II-IVA tongue cancer. 2. Patients who have undergone neck dissection and whose intact lateral tongue molars, tongue base, and intact lateral tongue muscles remain after resection of the primary tumor.
Exclusion criteria
Exclusion criteria: Exclusion Criterion 1 (at the time of first-stage registration) 1. Individuals with stage 0, I, or stage IVB-C tongue cancer 2. Among patients with stage II tongue cancer, those who only undergo partial resection of the tongue without reconstruction after removal of the primary lesion 3. Individuals with a history or complications of other psychiatric or neurological disorders (including regular prescriptions for tranquilizers or antidepressants and on-demand or internal use of psychotropic medications) 4. Individuals with metal inside the skull (excluding titanium cranial plates less than 1mm and dental fillings) 5. Individuals equipped with medical pumps or cardiac pacemakers 6. Individuals with a history of epilepsy 7. Individuals classified as clinical severity level 1 or below for dementia, cerebrovascular disease, postoperative occlusal disorder, or eating and swallowing disorders 8. Individuals with comorbidities of cardiovascular or respiratory diseases such as myocardial infarction, angina, hypertension (systolic blood pressure 200/diastolic blood pressure 120 mmHg or higher), deep vein thrombosis, chronic respiratory failure, posing a risk for exercise 9. Individuals with significant hearing impairment who cannot communicate 10. Pregnant individuals, or those who may become pregnant during the study period 11. Individuals with a history of contrast agent allergy 12. Individuals deemed ineligible based on referencing medical records or referral letters concerning the pre-checklist of transcutaneous electrical stimulation 13. Other individuals deemed inappropriate by the research principal or co-investigator. Exclusion Criteria 2 (Second-Stage Enrollment) 1. Patients with postoperative delirium, dementia, or other psychiatric disorders who are unable to receive adequate treatment are excluded. 2. Patients with poor postoperative general condition or other complications who are unable to receive adequate treatment are excluded. 3. Patients who underwent laryngeal lift surgery after primary tumor resection are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.MBSImP (Modified Barium Dysphagia Profile) 2.Measurement of tongue pressure using the tongue pressure measuring device (TPM-02E) | — |
Secondary
| Measure | Time frame |
|---|---|
| Dysphagia Severity Scale, Functional oral intake scale, Hyodo Score,VF video analysis using 2D analysis software | — |
Contacts
Public ContactHideki Okamoto
Nagoya City University
Outcome results
None listed