Healthy Adults
Conditions
Interventions
The study will be a randomized, crossover, comparative study of three groups of the same study subjects receiving saline (Group 1), or propofol (Group 2). The study will be conducted in a single blind
Sponsors
Kishimoto Toshiyuki
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: (1) Healthy adult males between the ages of 20 and 39 (2) Those who have given their consent to participate in this research by signing the consent form.
Exclusion criteria
Exclusion criteria: (1) Persons at risk of airway obstruction (obesity, history of sleep apnea syndrome, etc.) (2) Patients with a history of hypersensitivity to any of the ingredients of Propofol (3) Patients taking psychotropic drugs (including those taking sleeping pills or other drugs taken on an ad-hoc basis) (4) Patients with serious hepatic disorder, renal disorder, respiratory disease, or cardiac disease (5) Patients with an implantable pacemaker or an implantable cardioverter-defibrillator (6) Persons who are judged to be ineligible by the principal investigator (dentist).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Eye potential (blink intensity, blink duration, blink frequency) | — |
Secondary
| Measure | Time frame |
|---|---|
| Body sway, BIS (electroencephalogram spectrum) values, Modified Observer's Assessment of Alertness/Sedation (MOAA/S), directed behavior, cognitive ability, Trieger Dot Test, center of gravity sway distance and area, cardiovascular parameters (blood pressure, pulse rate), respiratory parameters (arterial blood oxygen saturation (SpO2), expiratory terminal carbon dioxide partial pressure (etCO2), respiratory rate), incidence of adverse events and failures | — |
Contacts
Public ContactToshiyuki Kishimoto
Asahi University Medical & Dental Center
Outcome results
None listed