prolonged consciousness disorder Neurorehabilitation, transcranial direct current, consciousness disturbance
Conditions
Interventions
Patients will be randomly assigned to Treatment Group A or Treatment Group B immediately after enrollment, and stimulation with tDCS (Compact DC Stimulator GD-800, OG Wellness Corporation) will be per
tDCS
Sponsors
Takahashi Chiaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with consciousness disorders persisting for more than 3 months due to traumatic brain injury, stroke, inflammatory brain diseases, hypoxic or metabolic encephalopathy. 2.Patients classified as MCS or UWS in terms of disease type. 3.Age at consent acquisition: 20 to 90 years old (However, individuals who were capable of making independent decisions in daily life and expressing their intentions before the onset of illness). 4.Prior to participation in this study, written consent is obtained either from the relatives up to the second degree of kinship, based on their voluntary decision, or from the patient's family if the patient is unable to make judgments, following sufficient informed consent.
Exclusion criteria
Exclusion criteria: 1.Patients with poorly controlled epilepsy ( occurring within the past 1 years) 2. Patients with cranial bone defects due to decompression surgery 3. Patients with extensive titanium mesh or artificial bone insertion directly beneath the planned stimulation site following cranioplasty 4. Psychiatric disorders 5. Patients with inserted extradural electrodes, DBS electrodes, ITB pumps, or spinal cord stimulation devices 6. Patients with troubles such as dermatitis and skin cancer at the site of planned electrode attachment 7. Patients with pacemakers or ICDs 8. Pregnant women 9. Complication of malignant tumor 10. Tendency of hemorrhage 11. People with acute illnesses such as infectious diseases, febrile diseases, tuberculousis 12. Abnormal blood pressure: Cases deviating from the average blood pressure of 60 mmHg to 150 mmHg 13. Individuals diagnosed with osteoporosis 14. Individuals have recieved botulinum therapy within 3 month 15. Cases deemed inappropriate as subjects for the study by the principal investigator or co-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in CRS-R Score (Coma Recovery Score-Revised) | — |
Secondary
| Measure | Time frame |
|---|---|
| *Comparison of NPS (Normalized activity topography) and NPV (Normalized power variance) between pre-stimulation and post-stimulation: *AI (Asymmetry Index) of theta, alpha, and beta frequency bands in F3F4, O1O2, CzOz, and FpzOz brain regions. *Triple correlation values of brainwaves (F3F4Fpz, C1C2Oz). *Frequency evaluation of alpha waves in the occipital lobe during the course of treatment. Occurrence of adverse events. | — |
Contacts
Public ContactChiaki Takahashi
Kanazawa Medical University Hospital
Outcome results
None listed