Validation of the accuracy of a treatment prediction system for severe hyponatremia

Validation of the accuracy of a machine learning-based treatment prediction system for severe hyponatremia

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs042230147

Enrollment

Registered

2024-02-06

Start date

2024-10-30

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hyponatremia

Interventions

At the start of treatment, the serum Na concentration, serum K concentration, serum Cl concentration, and the expected volume of drinking water up to 6 hours after the time of use of the prediction sy

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who have given written consent and are undergoing inpatient treatment for correction of hyponatremia (serum sodium concentration <130 mEq/L) at Nagoya University Hospital, its affiliated facilities, and Gifu University Hospital.

Exclusion criteria

Exclusion criteria: 1. Patients with urinary sodium concentration less than 20 mEq/L at enrolment 2. Patients using high-dose steroids (hydrocortisone equivalent >30 mg/day) at enrolment

Design outcomes

Primary

Measure	Time frame
Percentage of measured serum sodium concentration within +/- 2 mEq/L of the predicted serum sodium concentration at 12 hours after the start of treatment	—

Secondary

Measure	Time frame
1. Percentage of measured serum sodium concentration within +/- 2 mEq/L of the predicted serum sodium concentration at 6 hours after the start of treatment 2. Percentage of measured serum sodium concentration within +/- 2 mEq/L of the predicted serum sodium concentration measured every 6 hours after 12 hours of the start of treatment 3. Accuracy of the prediction system for treatment of hyponatremia	—

Measure

Time frame

1. Percentage of measured serum sodium concentration within +/- 2 mEq/L of the predicted serum sodium concentration at 6 hours after the start of treatment 2. Percentage of measured serum sodium concentration within +/- 2 mEq/L of the predicted serum sodium concentration measured every 6 hours after 12 hours of the start of treatment 3. Accuracy of the prediction system for treatment of hyponatremia

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Contacts

Public ContactSatoshi Naito

Nagoya University Graduate School of Medicine

naito.satoshi@med.nagoya-u.ac.jp+81-52-744-2142

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026