Neurological diseases
Conditions
Interventions
Gait practice is performed while applying electrical stimulation such as tDCS (transcranial direct current stimulation) and tACS (transcranial alternating current stimulation).
Stimulating electrodes
Sponsors
Ueki Yoshino
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients with established diagnosis of Parkinson's disease and Parkinson's syndrome (progressive supranuclear palsy, basal ganglia cortical degeneration, dementia with Lewy bodies, multiple system atrophy, cerebrovascular parkinsonism, normal pressure hydrocephalus, etc.), corticospinal tract disorder (stroke, encephalitis, etc.) and cerebellar ataxia (spinocerebellar degeneration, etc.) by the Department of Neurology 2.Age: 40-90 years old 3. Persons who can walk on the floor or treadmill using free hands or handrails 4.Patients who have obtained written consent for participation in this study from the patients themselves or their surrogates
Exclusion criteria
Exclusion criteria: 1.History or complication of other neuropsychiatric disorders 2. If you have metal such as a clip in your skull 3. Have a cardiac pacemaker 4. Has a history of epilepsy 5.History of limb joint or spine surgery 6. Cardiovascular and respiratory diseases such as myocardial infarction, angina pectoris, hypertension, deep vein thrombosis, chronic respiratory failure, etc. and at risk for exercise 7. Having metals in the body that cannot be confirmed as non-magnetic, such as nerve stimulators, aneurysm clips, insulin pumps, stents, intraocular metals, etc. 8. If you have severe hearing impairment and are unable to communicate 9. Pregnant women, those who may be pregnant 10.In addition, if the researcher or co-investigator judges it to be inappropriate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of gait function (gait speed and gait variability) between brain stimulation and sham stimulation interventions | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.MDS-Unified Parkinson's Disease Rating Scale 2.Quantitative values of motor cortex excitability using TMS and surface electromyography 3.Correlation of functional connectivity between regions of the movement-related network using resting-state fMRI 4.Body movement measurement value 5.Electrophysiological assessment | — |
Contacts
Public ContactYoshino Ueki
Mirai Kousei Hospital, Nagoya City University School of Medicine
Outcome results
None listed