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Examination of usefulness of iATP function (Proof of concept test in humans)

Examination of usefulness of iATP function (Proof of concept test in humans)

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs042210081
Enrollment
48
Registered
2021-10-07
Start date
2021-11-18
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fatal ventricular arrhythmia

Interventions

Implantable cardioverter-defibrillator transplantation is performed for fatal ventricular arrhythmia, and iATP and conventional ATP are performed in the treatment.

Sponsors

Yoshihisa Naruse
Lead Sponsor
MEDTRONIC JAPAN CO., LTD.
Collaborator

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Patients over 20 years old 2. Patients diagnosed with persistent ventricular tachycardia due to organic heart disease and scheduled to undergo electrophysiological examination and catheter ablation for therapeutic purposes 3. Patients who are scheduled to undergo or have already been implanted with an implantable cardioverter-defibrillator (Medtronic Cobalt XT) transplantation prior to ablation treatment

Exclusion criteria

Exclusion criteria: 1. Patients less than 3 months after the onset of myocardial infarction 2. Patients who are dependent on catecholamines 3. Patients who are judged to be inappropriate for registration in this study by the investigator and the investigator

Design outcomes

Primary

MeasureTime frame
Validity of iATP settings automatically calculated by ICD

Secondary

MeasureTime frame
1) The following comparison between the conventional ATP group and the iATP group (details of the success rate of ventricular tachycardia arrest by A-1 ATP and the failure of ventricular tachycardia arrest by A-2 ATP [increased heart rate of ventricular tachycardia, ventricular fibrillation] Activation, reinduction after VT stop, Pacing non capture, unsuccessful entry into VT circuit, unsuccessful entry into Termination zone]) 2) Detailed examination of the intracardiac potential when VT is stopped (excitation propagation time, etc.) 3) Examination of predictors of success / failure in the first treatment 4) Examination of predictors of success / failure in treatment up to the final sequence

Contacts

Public ContactNaruse Yoshihisa

Hamamatsu University School of Medicine

ynaruse@hama-med.ac.jp+81-53-435-2356

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026