Resistant hypertension
Conditions
Interventions
Assessing safety and effectivess of renal sympathetic denervation in Japanese patients by the method of muscle sympathetic nerve activity
Sponsors
Takamura Masayuki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients whose systolic pressure is beyond 160mmHg in spite of taking more than 3 kinds of antihypertensive drug(patients whose systolic pressure is beyond 150mmHg, if he is a diabetic)
Exclusion criteria
Exclusion criteria: 1)Anatomical anomaly of renal artery inappropriate for the operation 2)Estimated glomerular filtration rate is less than 45mL/min 3)History of myocardial infarction, angina pectoris, or cerebrovascular accident within 6 month 4)Type1 diabetes mellitus 5)Secondary Hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1)Safety during perioperative period and chronic phase after the operation(evaluated with eGFR and imaging study) 2)Onset or progression of cardiovascular disease | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Safety of the technique in the operation 2)Systolic blood pressure one year after the operation 3)Sympathetic nerve activity after the operartion(evaluated with muscle sympathetic nerve activity and blood hormone such as catecholamine) | — |
Contacts
Public ContactHisayoshi Murai
Kanazawa University Hospital
Outcome results
None listed