Gastric cancer Gut microbiome
Conditions
Interventions
Participants will be allocated to either a kestose intake group or a non-intake (control) group.
In the kestose intervention group, oral administration of kestose at a dose of 6 g/day will be initiate
C072433
Sponsors
Suda Koichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who have provided written informed consent to participate in this study after receiving a full explanation of the study. 2. Patients aged 20 years or older and younger than 90 years at the time of obtaining informed consent. 3. Patients with a pathological diagnosis of gastric cancer who are scheduled to undergo distal or total gastrectomy at Fujita Health University Hospital.
Exclusion criteria
Exclusion criteria: 1. History of small or large bowel resection (appendectomy permitted). 2. Receipt of preoperative chemotherapy. 3. Regular use of probiotics or gastrointestinal agents (gut-modulating agents) prior to surgery. 4.Severe constipation likely to preclude stool sample collection. 5.Any other condition that, in the opinion of the principal investigator or sub-investigators, renders the patient unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change from baseline in the proportion of short-chain fatty acid-producing bacteria in the gut microbiota at 3 months after gastrectomy | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage of body weight loss at 3 months after gastrectomy 2. Clinical nutritional parameters at 3 months after gastrectomy, including serum albumin, prealbumin, cholesterol, cholinesterase, and related markers Association between the gut microbiota and post-gastrectomy syndrome Proportion of short chain fatty acid producing bacteria at 12 months postoperatively (change from baseline) Percentage of body weight loss at 12 months postoperatively Sarcopenia and body composition assessment (at 3, 6, and 12 months postoperatively) | — |
Contacts
Public ContactTsuyoshi Tanaka
Department of Surgery, Fujita Health University Hospital
Outcome results
None listed