Idiopathic olfactory dysfunction Idiopathic olfactory dysfunction
Conditions
Interventions
Study participants will be randomly assigned to either the soup food group or the olfactory training kit group at the time of enrollment.
Participants in the soup food group will take the soup food on
D000094562
Sponsors
Shiga Hideaki
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Idiopathic olfactory dysfunction. 2) No apparent cause in medical history, such as common cold (including COVID-19), head trauma, or dementia. 3) No abnormal findings in the nasal sinuses on nasal fiberoptic or sinus CT. 4) No significant intracranial cerebral atrophy, cerebrovascular disease, or brain tumor on head MRI. 5) Average of odor recognition threshold in T&T olfactometry of 2.6 to 4.0 (moderately depressed) or 4.2 to 5.4 (severely depressed). 6) Age is 50 years or older. 7) Gender is unspecified. 8) Outpatients. 9) Independent in daily activities. 10) Written informed consent has been obtained from the patient, freely given after a sufficient explanation of the study and before participation.
Exclusion criteria
Exclusion criteria: 1) Patients with olfactory dysfunction for more than 3 years. 2) Patients who received olfactory stimulation therapy within 1 month prior to the start of the study. 3) Patients taking oral steroids, nasal steroids, zinc preparations, vitamin B12 preparations or Chinese herbal preparations. 4) Patients with a threshold value exceeding 8 dB in either the right or left tympanic nerve area in an electrical taste test. 5) Patients with a history of airway hypersensitivity disease such as poorly controlled asthma. 6) Patients with a history of food allergy, or with a positive test result for allergens that cause food allergy in allergy test View 39. 7) Patients suffering from or with a history of serious internal organ diseases. 8) Patients who are deemed inappropriate as study participants by the principal investigator or a physician in charge of the research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Average of odor recognition threshold in T&T olfactometry | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of correct answers to the card-based olfactory identification ability test (Open Essence), results of the daily smell questionnaire, questionnaires on diet and health status, olfactory stimulus/meal record card, and percentage of adverse event occurrence. | — |
Contacts
Public ContactHideaki Shiga
Kanazawa Medical University
Outcome results
None listed