digestive disease gastrointestinal disease, hepato-biliary-pancreatic disease
Conditions
Interventions
A single 500 mg dose of hydrocortisone intravenously is administered immediately before the surgery.
hydrocortisone
Sponsors
Yokoyama Yukihiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients scheduled for digestive surgery, including laparotomy, laparoscopic gastrointestinal surgery, laparoscopic hepatectomy, robot-assisted hepatectomy, laparoscopic distal pancreatectomy, robot-assisted pancreatic surgery and laparoscopic cholecystectomy for cholecystitis. 2)Patients who have understood and agreed the concept of the study. 3)Age more than 65, regardless of gender.
Exclusion criteria
Exclusion criteria: 1)Patients with allergic to hydrocortisone. 2)Patients receiving systemic corticoids or immunosuppressive therapy. 3)Patients with active peptic ulcer disease. 4)Patients with insulin-dependent diabetes mellitus. 5)Patients with a history of stroke within 3 months. 6) Patients with no history of measles or varicella and who have not been vaccinated. 7) Patients with a history of hepatitis B or hepatitis C. 8)Patients with severe communication disorders in vision or hearing 9)Patients with unstable mental status or psychiatric disorders. 10)Patients who are currently participating in other intervention studies that may affect the results of this study. 11)Patients scheduled for inguinal hernia surgery and laparoscopic cholecystectomy for non-inflammatory gallbladder stones or gallbladder polyps. 12)Patients undergoing emergency surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of delirium during the first 3 days after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Change in blood sodium levels on postoperative days 1 and 3 compared to preoperative levels 2)Death within 90 days of surgery 3)Postoperative hospital stay 4)Change in FIM (functional independence measure) from admission to discharge. 5)Identification of predictors of delirium up to the third postoperative day, and construction of a formula for predicting the probability of delirium | — |
Contacts
Public ContactTomoki Ebata
Nagoya University Hospital
Outcome results
None listed