hypotension hypotension, elective caesarean section, non-reassuring fetal status
Conditions
Interventions
In the study treatment group, administration of phenylephrine hydrochloride (0.5 mcg/kg/min) is initiated prior to spinal anesthesia. The administration of phenylephrine hydrochloride prior to spinal
D02.033.100.291.617, D02.092.063.291.617
Prophylactic vasopressor administration
Sponsors
Magawa Shoichi
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1) Age 18 years or older 2) Elective cesarean section after 37 weeks of pregnancy 3) Singleton pregnancy 4) Written consent has been obtained from the patient
Exclusion criteria
Exclusion criteria: Patients with hypertension systolic blood pressure over140 mmHg or diastolic blood pressure over90 mmHg) at the time of registration Patients with cardiac, vascular, renal, or coagulation disorders Patients with pregnancy-related complications, hypertension, gestational hypertension, chronic kidney disease, etc. Those with either amniotic fluid abnormalities or fetal growth retardation Those with fetal malformations that affect umbilical artery blood gas analysis and neonatal respiratory support after birth Those with drug allergy to phenylephrine hydrochloride Those who are judged by the principal investigator/associate investigator to be inappropriate as subjects for this clinical trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maternal blood pressure variability from spinal anesthesia to delivery of the infant (evaluation period) | — |
Secondary
| Measure | Time frame |
|---|---|
| Group differences in maternal and neonatal background maternal-related information, age, delivery week, complications, height, pre-pregnancy weight, weight at delivery, number of births, neonatal-related information, sex, APGAR Score, 1 min value 5 min value, height, weight Blood pressure related parameters Number of occurrence of hypotension measured by brachial manchette, maximum systolic blood pressure, minimum systolic blood pressure, maximum diastolic blood pressure, minimum systolic blood pressure, maternal blood pressure changes during the observation period maximum systolic blood pressure manus minimum systolic blood pressure, maximum diastolic blood pressure mainus minimum diastolic blood pressure Occurrence of hypotension measured by CLEARSIGHT, maximum systolic blood pressure, minimum systolic blood pressure, maximum diastolic blood pressure, minimum systolic blood pressure, course of maternal cardiac output, and changes in maternal blood pressure during the observation period maximum systolic blood pressure mainus minimum systolic blood pressure maximum diastolic blood pressure mainus minimum diastolic blood pressure Neonatal effects: umbilical cord blood gas analysis, pH, Base Ecess, pCO2, pO2, neonatal blood glucose,after birth, Neonatal blood glucose,from blood tests in the NICU after birth, frequency of neonatal respiratory support needs,for respiratory support required after postnatal resuscitation, NICU admission, and NICU admission. initial blood test findings after admission to the NICU, blood gas analysis, Placental weight Total dose of phenylephrine hydrochloride, mg; from the start of lumbar anesthesia to the delivery of the infant, and from the start of lumbar anesthesia to the end of surgery | — |
Contacts
Public ContactShoichi Magawa
Mie university hospital
Outcome results
None listed