Spine/spinal cord disease Spine/spinal cord disease
Conditions
Interventions
The motor evoked potentials are measured after changing from general anesthesia using propofol to general anesthesia using remimazolam.
Sponsors
Kuwabara Takahiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients aged 6 months or older and younger than 18 years who will undergo surgery under general anesthesia and whose motor evoked potentials will be measured during surgery.
Exclusion criteria
Exclusion criteria: Age 18 years or older Patients who are assumed to be allergic to propofol Patients whose baseline MEP could not be measured with propofol Case where it is considered difficult to continue the research based on the judgment of the attending department and anesthesiology department Patients who are judged to be unsuitable for participation in this study by the principal investigator or co-investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentage of cases in which surgery was started with remimazolam anesthesia after confirming that the MEP of the trapezius muscle in cervical spine cases, and the deltoid muscle and abductor digiti minimi muscle in thoracolumbar spine cases, did not decrease in amplitude under remimazolam anesthesia by more than 70% of the amplitude under propofol anesthesia. | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of cases in which surgery could be completed with remimazolam anesthesia MEP derivation, amplitude, and latency for each muscle in the first MEP measurement after the introduction of propofol and remimazolam Anesthesia induction time Time from completion of surgery to extubation Time from completion of surgery to leaving the room Difference in cost of drugs used Adverse event Incidence rate of postoperative paralysis Changes in MEP derivation, amplitude, and latency from the start of surgery to the end of surgery Percentage of MEP recovery cases after restarting propofol | — |
Contacts
Public ContactTakahiro Kuwabara
Nagoya University School of Medicine Hospital
Outcome results
None listed