Coronary artery disease, aortic disease and aortic valve disease in adult Coronary Artery Disease, Aortic Diseases, Aortic Valve Disease
Conditions
Interventions
After aortic cross clamp, we will start to infusion trial or placebo drugs at 1.5 mL/hour.Targeted mean arterial pressure is 60 mmHg at arterial line monitoring or non invasive blood pressure.
1 bloo
Randomized Controlled Trial
Sponsors
Akiyama Koichi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Male and Female Age 18 years old to 85 years old weight 40kg to 120kg Patients underwent cardiovascular surgery with cardiopulmonary bypass Understand the research and obtain written consent
Exclusion criteria
Exclusion criteria: Chronic or paroximal atrial fibrillation mitral valve surgery minimally invasive cardiac surgery non median sternotomy hyponatremia Chronic kidney disease on hemodialysis Patients who is not eligible for candidate for trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcome is rate of post operative atrial fibrillation within 3 days. In blinded manner, responsible investigator or subinvestigator will investigate ocurring postoperative atrial fibrillation from ICU monitoring record. | — |
Secondary
| Measure | Time frame |
|---|---|
| 30 day mortality, ischemic stroke, postoperative 48 hours over ventilation, acute kidney disease, rate of ischemic colitis, ICU stay, days of event postoperative atrial fibrillation, hospital stay, cost of ICU care, Hospital costs, VIS of intraoperative period and staying ICU period, total vasoactive use of intraoperative period and staying ICU period. | — |
Contacts
Public ContactKochi Yamane
Nagoya University hospital
Outcome results
None listed