Evaluation of arginine-stimulating test for diagnosis of central diabetes insipidus

Evaluation of usefulness of plasma arginine vasopressin measurement in arginine-stimulating test for diagnosis of central diabetes insipidus

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs041220082

Enrollment

Registered

2022-10-26

Start date

2022-10-26

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Central diabetes insipidus

Interventions

Arginine stimulating test: Arinine 0.5 g/kg (intervenous administration for 30 min) Blood collection before administration and 30, 60, 90, and 120 min after start of administration Total volume of blo

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients below who consent to participate in this study in writing 1. Patients suspected as central diabetes insipidus 2. Patients already diagnosed as central diabetes insipidus 3. Patients with diencephalohypophysial diseases and no symptoms of diabetes insipidus

Exclusion criteria

Exclusion criteria: 1. Patients with heart and renal failure 2. Patients with bronchial asthma Pregnant or breastfeeding patients 3. Patients considered inappropriate for the participation in this study by doctors

Design outcomes

Primary

Measure	Time frame
Sensitivity of arginine stimulating test in diagnosis of central diabetes insipidus	—

Secondary

Measure	Time frame
Specificity of arginine stimulating test in diagnosis of central diabetes insipidus Incidence of adverse events Association between vasopressin concentrations measured by RIA or the LC-MS/MS method and serum sodium levels Comparison of diagnostic accuracy of central diabetes insipidus using vasopressin or copeptin measurements	—

Contacts

Public ContactDaisuke Hagiwara

Nagoya University Hospital

d-hagiwara@med.nagoya-u.ac.jp+81-52-744-2142

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026