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Effects on Respiratory Compliance with Sugammadex in Children on Ventilation

A prospective interventional study on the effect of antagonizing muscle relaxation with sugammadex on respiratory compliance in ventilated children.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs041220060
Enrollment
55
Registered
2022-08-30
Start date
2022-09-22
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Persons undergoing surgery under general anesthesia

Interventions

In pediatric patients undergoing general anesthesia with tracheal intubation, the EIT System Enlight 2100 is worn to observe respiratory compliance during sugammadex administration.

Sponsors

Yagihara Masahiro
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. children between 2 and 12 years of age 2. who will undergo scheduled surgery under general anesthesia 3. who are scheduled to be intubated with muscle relaxation 4. who will undergo surgery in the supine position 5. who have obtained consent for participation in this study by signing a consent form by a surrogate

Exclusion criteria

Exclusion criteria: 1. who are allergic to rocuronium or sugammadex 2. who have respiratory complications such as asthma or active upper airway inflammation as a preoperative complication 3. Patients with skin disease in the area of the EIT 4. Persons with a chest measurement of less than 50 cm 5. Patients with upper abdominal or thoracic surgery that precludes thoracic EIT. 6. who cannot wear an EIT due to thoracic deformity 7. Patients with congenital heart disease requiring treatment 8. patients with neuromuscular diseases 9. patients with liver or kidney dysfunction 9. who have hepatic or renal dysfunction 10. other persons whom the principal investigator or subinvestigator determines are not appropriate to be included in this study

Design outcomes

Primary

MeasureTime frame
Changes in respiratory compliance before and after sugammadex administration

Secondary

MeasureTime frame
Changes in air content distribution before and after sugammadex administration Correlation of changes in respiratory compliance with age, weight, and BMI Presence or absence of adverse events

Contacts

Public ContactChiharu Wakuda

Hamamatsu University Hospital

chiharu0204wakuda@yahoo.co.jp+81-53-435-2738

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026