None
Conditions
Interventions
Research drug regimen
1)Esomeprazole 20mg 1 tablet 1 after supper +oral administration by 200ml of water
2)Bonoprazan 10mg 1 tablet 1 after supper+oral administration with water 200ml
3)Bonoprazan 10
Sponsors
Mihoko Yamade
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Healthy subjects who are at least 18 years old at the time of consent. Who are able to abstain from alcohol and smoking while taking the study medication and for 14 to 28 days during the washout period Who have signed a consent form to participate in this study.
Exclusion criteria
Exclusion criteria: 1. Those with a history of gastric ulcer 2. Those with a history of myocardial infarction 3. Those with serious liver disease (>3 times the reference value) 4. Patients with serious renal disease (Cre > 1.5) 5. Patients who have undergone abdominal surgery 6. Those who have other serious diseases 7. Who are receiving continuous medical treatment during the study period 8. who are receiving continuous medical treatment during the study period 8. Who are allergic to any of the study drugs (esomeprazole or bonoprazan) 9. Pregnant women and those who wish to deliver a baby during the study period; 10.Persons who are deemed inappropriate by the investigator (subinvestigator).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Carbon isotope ratio (13CO2/12CO2) of carbon dioxide in 13C-aminopyrine breath samples after VPZ and EPZ oral administration | — |
Secondary
| Measure | Time frame |
|---|---|
| Frequency of adverse events | — |
Contacts
Public ContactTakahashi Satoru
Hamamatsu University Hospital
Outcome results
None listed