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A prospective study comparing the effects of intramyometrial and continuous intravenous injection of oxytocin

A prospective study comparing the effects of intramyometrial and continuous intravenous injection of oxytocin to maintain uterine contractions in the prevention of postpartum hemorrhage by cesarean section

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs041210153
Enrollment
24
Registered
2022-03-02
Start date
2022-04-25
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

none

Interventions

Patients undergoing cesarean section will receive oxytocin uterine infusion or continuous intravenous oxytocin after delivery of the baby, and total blood loss will be assessed up to 2 hours after ret

Sponsors

Naruse Satoshi
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: 1. Preoperative ASA-PS (ASA physical status) 2 2. Singleton 3. 37 weeks or more gestation 4.Patients scheduled for elective cesarean section with spinal stem anesthesia 5.Those who are between 20 and 40 years old at the time of obtaining consent. 6.Those who have given their consent for this study by signing the consent form.

Exclusion criteria

Exclusion criteria: 1. Obvious obstetric diseases (uterine fibroids, uterine adenomyosis, endometriotic cysts, giant baby, excessive amniotic fluid, gestational hypertension), cardiac diseases 2. Patients with obvious obstetrical diseases (uterine fibroids, endometrial cysts, giant babies, excessive amniotic fluid, gestational hypertension), cardiac diseases, blood coagulation abnormalities, and spinal diseases that would make it difficult to perform spinal stem anesthesia Those who are in labor. 3. Those whose water has broken. 4.Those with abnormal placental position 5. Those with other placental abnormalities 6. Those with multiple pregnancies 7.Those with uterine malformation 8.Those with oxytocin allergy 9. Obesity (BMI above 30 at 35-36 weeks gestation) 10. Those who have had 3 or more deliveries 11.Those who have a history of postpartum hemorrhage. 12.Those who are judged by the principal investigator or sub-investigator to be inappropriate for inclusion in this study.

Design outcomes

Primary

MeasureTime frame
Total blood loss from intraoperative to 2 hours after returning to the ward

Secondary

MeasureTime frame
1. frequency of postpartum hemorrhage (total blood volume >1000 mL) 2. degree of uterine contractions (2 hours after return to the ward) 3. presence of additional oxytocin and total additional dose (from intraoperative to 2 hours after return to the ward) 4. uterine contractions other than oxytocin (methyl erythrocyte) 4. use of uterine contractions other than oxytocin (methylergometrine, prostaglandin F2) 5. surgical intervention (B-Lynch suture, balloon tamponade, gauze tamponade, vascular ligation, hysterectomy, arterial embolization (Interventional Radiology:IVR)) 6. presence and frequency of fundus massage 7.Number of cases of refractory flaccid hemorrhage 8.Blood transfusion 9.Length of hospital stay 10. total dose of phenylephrine after delivery of the child 11. changes in vital signs (blood pressure, heart rate, cardiac output, and cardiac output per cycle)

Contacts

Public ContactSatoshi Naruse

Hamamatsu University Hospital

07483931@hama-med.ac.jp+81-53-435-4176

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026