Food Allergy Food Allergy
Conditions
Interventions
Daily intake group of test meal (causing food alone)
Daily intake group of test meal (cause food and lactic acid bacterium L-137 combined)
Implementation of allocation to standard instruction groups
Sponsors
Kondo Yasuto
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients who have received sufficient explanation before participating in this study, and who have obtained written consent at the discretion of the patient or his / her substitute with sufficient understanding. 2. Patients aged 6 months to 18 at the time of consent 3. Patients diagnosed by a doctor as having a chicken egg, milk or wheat allergy 4. Patients with threshold values between 0.1 g and 18 g of heated egg white, 0.1 mL and 50 mL of milk, and 0.1 g and 50 g of udon noodles in an oral food challenge test conducted within the past 3 months
Exclusion criteria
Exclusion criteria: 1. Patients with severe anaphylaxis due to ingestion of causative foods of 0.1 g, 0.1 mL or less within the past year 2. Patients with severe complications 3. In addition, patients who are judged to be inappropriate by the principal investigator and the research coordinator 4. Patients who consume causative foods above the confirmed threshold at home
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ingestible amount of causative food in food oral challenge test 24 weeks after the start of the test | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in the presence / absence and frequency of induced symptoms during the study period Differences between groups of adherence Differences between groups in the burden of parents Differences between groups of specific IgE antibody titers (egg white, ovomucoid, milk, casein, wheat, omega-5 gliadin)-Specific IgG4 antibody titer Differences in the number of Treg cells between groups Differences between gut microbiota ratios and fecal short-chain fatty acid analysis values | — |
Contacts
Public ContactNakajima Yoichi
Fujita Health University Department of pediatrics
Outcome results
None listed