Stomach cancer
Conditions
Interventions
Taking ramelteon of 8 mg will be started 7 days before the operation. Ramelteon will be then resumed from the resume of drinking water and be continued until discharge.
Sponsors
Terashima Masanori
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Histologically proven adenocarcinoma of the stomach (including special types of gastric cancer such as endocrine cell carcinoma (NEC), carcinoid tumors, and Siewert type II/III esophagogastric junction carcinoma.) 2) Planned radical gastrectomy other than local resection 3) Age>=75 years old 4) PS 0 or 1 5) Oral medication able to be ingested without bowel obstruction or bleeding 6) WBC >= 3,000 /mm3 PLT >= 100,000 /mm3 AST<=100 IU/L,ALT<=100 IU/L T-Bil<=2.0 mg/dl Cre<= 1.5 mg/dl 7)Written informed consent
Exclusion criteria
Exclusion criteria: 1) Dementia 2) Psychologic disorders (including habitual use of sleeping medicine, and alcoholism) 3) CAM-ICU not able to be performed 4) Habitual use of opioid or steroid (including inhalation, excluding ointment, nasal spray, eye-drops) 5) A history of hypersensitivity to ramelteon 6) Currently receiving fluvoxamine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative delirium | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative complication Adverse events related to ramelteon treatment | — |
Contacts
Public ContactKenichiro Furukawa
Shizuoka Cancer Center
Outcome results
None listed