Peripheral facial nerve palsy Facial palsy, intratympanic injection, steroid therapy
Conditions
Interventions
Intratympanic steroid therapy
Sponsors
Inagaki Akira
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Diagnosis as peripheral facial nerve palsy at Department of Otolaryngology-Head and Neck, Nagoya City University Hospital. 2.Diagnosis as a severe facial palsy of =20 years old who can give consent in writing.
Exclusion criteria
Exclusion criteria: 1.Presence of nonviral inflammation in the middle ear 2.Presence of bacterial disease at carriage state. 3.Presence of middle ear or inner ear anomaly that would make injection into middle ear impossible. 4.Glycated hemoglobin >=6.5%. 5.Creatinine clearance =100 U/l or aspartate transaminase >=100 U/l. 7.Severely protracted wound healing. 8.Signs of central facial palsy or other neurological disease that could potentially affect facial function 9.Pregnancy or possible pregnancy 10.Participation in other clinical trials within 3 months 11.History of dexamethasone treatment within 2 weeks 12.Recurrent facial palsy 13.Unable to properly conduct pure tone audiometry test, pitch match test, roundness balance test or tinnitus handicap inventory test. 14.Inappropriate for participation in the trial in the opinion of the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hearing threshold on pure tone audiogram | — |
Secondary
| Measure | Time frame |
|---|---|
| Pitchmatch test, loudness balance test, tinnitus handicap inventory,facial perineurium fluid and serum dexamethasone concentration, residual tympanic perforation | — |
Contacts
Public ContactAkira Inagaki
Nagoya City University Hospital
Outcome results
None listed