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Involvement of adenosine receptors with inhalation anesthetics

Involvement of adenosine receptors with inhalation anesthetics: a randomized controlled trial

Status
Active, not recruiting
Phases
Phase 1
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs041190124
Enrollment
20
Registered
2020-03-06
Start date
2021-01-21
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy adult

Interventions

Observe and evaluate hypnotic status and recovery process with sevoflurane alone, ATP alone, and sevoflurane and ATP combination

Sponsors

Sakurai Satoru
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: 1. Healthy adult men aged 20 to 39 2. Consent for study participation was obtained by signing consent form for this study

Exclusion criteria

Exclusion criteria: 1. Person who may cause airway obstruction (e.g.: obesity, sleep apnea syndrome) 2. Person who have previously used a halogenated anesthetic and have jaundice or an unexplained fever 3. Person with a history of hypersensitivity to sevoflurane 4. Person taking psychotropic drugs (including taking sleeping pills) 5. Person with serious liver disorder, kidney disorder, respiratory disease, heart disease 6. Person who is judged unqualified by the study responsible dentist or the study dentist

Design outcomes

Primary

MeasureTime frame
Depth of anesthesia (BIS)

Secondary

MeasureTime frame
Directed behavior, cognitive ability, psychomotor function, balanced motor function, circulation (heart rate, blood pressure, electrocardiogram), breathing (respiration rate, tidal volume, end-tidal carbon dioxide concentration, SpO2), and safety

Contacts

Public ContactToshiyuki Kishimoto

Asahi University School

kishimototoshiyuki@dent.asahi-u.ac.jp+81-58-329-1479

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026