The change of gut microbiota caused by Vonoprazan and kestose

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs041190016

Enrollment

Registered

2019-04-10

Start date

2018-03-19

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gastroduodenal ulcer and after ESD artificial ulcer

Interventions

Arm A : Kestose (10g) every day for 8 weeks Arm B : Maltose(5g) every day for 8week

Kestose

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients of gastroduodenal ulcer or after ESD artificial ulcer

Exclusion criteria

Exclusion criteria: 1. Patients continuously using PPI or Vonoprazan 2. Women with pregnancy or possible pregnancy 3. Patients with severe renal failure and heart failure 4. Patient who is considered to be inappropriate for entry into the trial by the investigator 5. Medical doctors decided the patients are inappropriate 6. Patient who has allergy to drugs or foods used in this research

Design outcomes

Primary

Measure	Time frame
the change of Gut microbiota caused by using Vonoprazan and kestose or placebo for 8 weeks	—

Secondary

Measure	Time frame
1. Observation of the change of ulcer healing caused by kestose 2. Changes of short-chain fatty acid (Butyric acid ,Acetic acid, Propionic acid etc.) 3. Changes of pathologic and metabolic marker (T-Cho, LDL-Cho, HDL-Cho, TG, FFA, ferritin, HbA1c, CRP, TP, ALB etc.) 4. Correlation of gut microbiota and bowel habits 5. Changes of body weight and BMI 6. Metabolome, bile acid and protein analysis of metabolite in feces 7. Correlation between expiratory noble gases, gut microbiota and ulcer healing	—

Measure

Time frame

1. Observation of the change of ulcer healing caused by kestose 2. Changes of short-chain fatty acid (Butyric acid ,Acetic acid, Propionic acid etc.) 3. Changes of pathologic and metabolic marker (T-Cho, LDL-Cho, HDL-Cho, TG, FFA, ferritin, HbA1c, CRP, TP, ALB etc.) 4. Correlation of gut microbiota and bowel habits 5. Changes of body weight and BMI 6. Metabolome, bile acid and protein analysis of metabolite in feces 7. Correlation between expiratory noble gases, gut microbiota and ulcer healing

—

Contacts

Public ContactSatoshi Furune

Nagoya University Hospital

s-furune@med.nagoya-u.ac.jp+81-52-741-2111

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026