Efficacy of oral tolerance induction by Kakkonto in food allergy - Non-Randomized clinical trial-

Efficacy of oral tolerance induction by Kakkonto in food allergy - Non-Randomized clinical trial- - Efficacy of Kakkonto for food allergy

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs041180068

Enrollment

Registered

2019-03-07

Start date

2017-12-13

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Food allergy Food allergy

Interventions

Take an intake instruction in a safe amount for a patient who is positive for oral food challenge test. We used Kakkonto for 24 weeks together and reevaluated the change in threshold by oral food chal

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Food allergy diagnosised by oral food challenge without tendency of natural outgrow 2. Children who obtain the informed consent of the study 3. Those who can take medicine of kakkonto 4. Patients who have secured medical institutions in emergency

Exclusion criteria

Exclusion criteria: 1.Complication or past history of heart, liver and kidney diseases. 2.Uncontrolled asthma, atopic dermatitis, allergic rhinitis 3.Children who were judged as inappropriate by the study director

Design outcomes

Primary

Measure	Time frame
1. Induced reaction during 24 weeks of treatment 2. Change of dose threshold in oral food challenge after 24 weeks of treatment 3. adverse reaction of kakkonto	—

Secondary

Measure	Time frame
1. Specific IgE/IgG4 antibody,cytokines,lymphocytes subsets 2. Compliance of kakkonto	—

Contacts

Public ContactTaisuke Kato

Toyama University Hospital

yaitto-tym@umin.net+81-76-434-7313

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026