Influence of daily or alternate-day dosing of vonoprazan on intragastric pH, serum gastrin and anti platelet function of clopidogrel

Influence of daily or alternate-day dosing of vonoprazan on intragastric pH, serum gastrin and anti platelet function of clopidogrel - Influence of daily or alternate-day dosing of vonoprazan

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs041180024

Enrollment

Registered

2018-12-28

Start date

2019-02-21

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Regimen1:VPZ(10mg) every other day + CLP(75mg) every day after breakfast Regimen2:VPZ(10mg) every day + CLP(75mg) every day after breakfast Regimen3:CLP(75mg) every day after breakfast

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Healthy adults over 20 years old. 2.For this research, those who obtained consent by signing the consent form by himself / herself. 3.Persons who are negative for anti-H. pylori IgG antibody, have not used the drugs in the past month.

Exclusion criteria

Exclusion criteria: 1.Persons who have a history of heart disease. 2.Persons with severe liver disease(AST:over 100 U/L). 3.Persons with severe kidney disease(Serum creatinine:over 1.3 mg/dl). 4.Women who are pregnant or may become pregnant. 5.A lactating women. 6.Those with upper gastrointestinal disorder, or those with a history. 7.H. pylori positive persons. 8.Those using drugs. 9.Smokers. 10.Those judged unsuitable by researcher or responsible responsibility sharing doctor.

Design outcomes

Primary

Measure	Time frame
pH4 HTR: pH holding time ratio	—

Secondary

Measure	Time frame
Serum gastrin level and IPA	—

Contacts

Public ContactTomohiro Higuchi

Hamamatsu University Hospital

thiguchi@hama-med.ac.jp+81-53-435-2261

Outcome results