Efficacy of rTMS for upper limb paralysis after stroke

Efficacy of the Functional Improvement Effects of Different Stimulation Methods of Repetitive Transcranial Magnetic Stimulation for Upper Limb Paralysis After Stroke: Randomized Controlled Trial

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs032250617

Enrollment

Registered

2026-01-07

Start date

2026-01-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

repetitive Transcranial Magnetic Stimulation

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Study1 (1) Age: 20-80 (2) Under the agreement with written consent form (3) Diagnosed as stroke by a physician (4) Inpatient at Chiba Rehabilitation Center (5) 2 months after onset (6) MEPs appears (7) Fugl-Meyer Assessment for upper extremity item of 20 or more (8) The weekly upper extremity motor score is limited to a change within the standard error for two consecutive weeks Study2 (1) Age: 20-80 (2) Under the agreement with written consent form (3) Diagnosed as stroke by a physician (4) Inpatient at Chiba Rehabilitation Center (5) 2 months after onset (6) MEPs does not appear. (7) Fugl-Meyer Assessment for upper extremity item are 19 points or less (8) The weekly upper extremity motor score is limited to a change within the standard error for two consecutive weeks

Exclusion criteria

Exclusion criteria: (1) Fit into following cases History of harmful sides effects due to magnetic or electrical stimulation. History of seizure or epilepsy. Disease or injury of head, brain, peripheral nerves including brain surgery prior to the onset of the current illness or injury. Medical device implantation such as cardiac pacemaker, neurosurgical clips, battery or pumps, non-titanium metal implants in the head or the stimulus target area of trunk. Chronic severe migraine, Suspicion of pregnancy (2) Buried metal cannot be identified as titanium. (3) Inappropriate patient decided by a physician (4) Current participation in clinical trials for an approved drug or clinical device (5) History of botulinum toxin therapy within 3 months (6) Over 57 points the FMA for upper extremity item

Design outcomes

Primary

Measure	Time frame
Fugl-Meyer Assessment for upper extremity item	—

Secondary

Measure	Time frame
Subtest scores Fugl-Meyer Assessment for upper extremity item, ARAT (Action Research Arm Test), BBT(Box & Block Test), Motor evoked potential elicited by transcranial magnetic stimulation, ipsilateral silent period by transcranial magnetic stimulation *Study2 only, Magnetic resonance imaging, Safety Assessments	—

Contacts

Public ContactTakashi Murayama

Chiba Rehabilitation Center

takashi.murayama@chiba-reha.jp+81-43-291-1831

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026