chronic heart failure with ventricular arrhythmia Refractory ventricular arrhythmia,chronic heart failure
Conditions
Interventions
Arrhythmia treatment by external radiation using X-ray equipment for cancer treatment
Sponsors
Yoshioka Koichiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Written consent to participate in the study has been obtained from the individual or a substitute 2)18 years of age or older 3)Have an implantable cardioverter defibrillator (ICD or CRTD) implanted 4)Chronic heart failure complicated by refractory ventricular arrhythmias (1) Sustained monomorphic ventricular tachycardia with 3 or more episodes, complicated by heart failure (HFrFF or HFpEF) (2) Cardiomyopathy resulting from ventricular premature beats (more than 20% of total heart beats) (HFrEF, EF less than 50%) Any of the above conditions with the following conditions Resistance to at least one antiarrhythmic drug or difficulty in taking them Patients with a history of at least one catheter ablation ,or non-eligible for catheter ablation or refusal of catheter ablation. 5) Regardless of whether you are hospitalized or outpatient
Exclusion criteria
Exclusion criteria: Heart failure dependent on left ventricular assist devices. Patients who are not expected to survive longer than 12 months due to factors other than VT. Polymorphic VT or ventricular fibrillation. Patients with three or more different clinical modes of VT. Structure heart disease requiring surgical treatment. Patients requiring inpatient treatment for acute coronary syndromes. High risk of radiation pneumonitis, e.g. with clear evidence of idiopathic pulmonary fibrosis on chest CT People with dementia, mental illness, or who require care. The principal investigator and assistant investigator judges that the patient is not suitable to participate in this study because of other diseases or reasons that make it difficult to carry out the necessary examinations or follow-up investigations.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Effectiveness Antiarrhythmic effect: Decrease in ventricular arrhythmias, decrease in ICD shock activation. Effect on cardiac function: Increase in ejection fraction, decrease in BNP. 2) Safety Radiation injury | — |
Secondary
| Measure | Time frame |
|---|---|
| Inhibition of sympathetic hyperactivity | — |
Contacts
Public ContactMari Amino
TOKAI UNIVERSITY SCHOOL OF MEDICINE HOSPITAL
Outcome results
None listed