Intractable Ventricular Arrhythmia
Conditions
Interventions
Arrhythmia treatment by Carbon ion therapy
Sponsors
Koto Masasi
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Written consent for participation in this study has been obtained from the patient or a substitute decision-maker at the time of obtaining consent 2) The patient is 18 years of age or older, Gender-neutral 3) The patient with a confirmed ventricular arrhythmia who fulfil the following conditions a) Persistent monomorphic ventricular tachycardia of 3 or more episodes b) Resistance to at least one anti-arrhythmic drug or cases where it is difficult to take medication c) Patients with a history of at least one catheter ablation, non-eligible for catheter ablation (anatomic difficulty, epicardial origin), or refusal of catheter ablation by the patient
Exclusion criteria
Exclusion criteria: 1) Previous radiation therapy to the irradiated area 2) Heart failure dependent on inotropic drugs or left ventricular assist devices 3) Cases with a low probability of survival for more than 6 months due to factors other than VT 4) Cases with polymorphic VT or ventricular fibrillation, 3 or more different clinical VT patterns, or 5 or more different inducible VT patterns in a non-invasive programmed stimulation test using an ICD 5) Cases undergoing maintenance hemodialysis or peritoneal dialysis 6) Patients who require hospitalization for acute coronary syndrome or acute heart failure 7) Patients who are at high risk of radiation pneumonitis, such as those with clear findings of idiopathic pulmonary fibrosis (IPF) on chest CT 8) Those who are pregnant or may be pregnant, or who are breastfeeding. 9) Those who are judged by the principal investigator or sub-investigator to be unsuitable for participation in this study, for example, if it is judged that it will be difficult to conduct the necessary tests or follow-up due to other diseases or reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) acute to subacute myocardium damage , presence or absence of lung damage and gastrointestine damage 2) Arrhythmic reduction effect, evaluation of stability of depolarization, repolarization and autonomic nerve index | — |
Secondary
| Measure | Time frame |
|---|---|
| Late effect of arrhythmia reduction and electrophysiological stability | — |
Contacts
Public ContactMayumi Ichikawa
Yamagata university, school of medicine
Outcome results
None listed