Mild cognitive impairment forgetfullness, MCI
Conditions
Interventions
Cognitive rehabilitation of 3 times per week during 2weeks, using computer training software for 40 minutes after repetitive transcranial magnetic stimulation (theta burst or sham stimulation) for 3mi
D015928, D050781
ognitive therapy, repetitive transcranial magnetic stimulation
Sponsors
Takakura Tomokazu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Be aware of forgetfulness. 2.Housework and activities of daily living are generally normal. 3.Age more than or equal to 60 years and less tha 80 years. 4.Those who can go to the hospital according to the test protocol. 5.Written informed consent to participate in this study.
Exclusion criteria
Exclusion criteria: 1.Under treatment for epilepsy/depression/mania/ schizophrenia. 2.Who have a cardiac pacemaker, implantable defibrillator, metal near the stimulation site (cochlear implant, magnetic clip, deep brain stimulation / vagus nerve stimulation), or implantable drug solution pump. 3. Severe heart disease:unstable angina,short-term myocardial infarction from onset, decompensated congestive heart failure, acute pulmonary heart, uncontrolled arrhythmia, severe aortic stenosis, active Myocarditis, endocarditis, etc. 4. Uncontrolled hypertension 5. Acute systemic illness or fever 6. Complications of recent pulmonary embolism, acute cor pulmonale, and severe pulmonary hypertension 7. Complication of severe hepatic / renal dysfunction 8. Severe orthopedic complications 9. Severe cognitive impairment (MMSE-J less tha or equal to 20/30), complications of severe mental illness 10. Other metabolic disorders (such as acute thyroiditis) 11. When using drugs that lower the threshold of spasm attacks (tricyclic antidepressants, maprotiline, theophylline, methylphenidate, ketamine, clozapine, zotepine) and abuse of alcohol, caffeine, stimulants, etc. 12. Lactating women 13. Other patients who are judged by the research-responsible (sharing) doctor to be inappropriate as research subjects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MOCA-J total score after the intervention, amount of change from baseline | — |
Secondary
| Measure | Time frame |
|---|---|
| Scores after the intervention as below. 1.MOCAJ subitems (visual space-execution system, naming, attention, language, abstract concept, delayed reproduction, orientation) 2.Spatial working memory (PUME on RehaCom software) 3.Digit Span (number of forward spans) 4.Verbal working memory, Reading Span Test (span score) 5.Word Fluency Test (total number of recalls) 6.Electrophysiological evaluations, RMT, SAI (ISI grand mean from 21 to 25ms) | — |
Contacts
Public ContactTomokazu Takakura
Juntendo Tokyo Koto Geriatric Medical Center
Outcome results
None listed