cervical dystonia
Conditions
Interventions
MR-guided focused ultrasound pallidothalamic tractotomy:
hair-shaved, frame fixation, MRI/CT, on the MRI/Exablate Transcranial MRgFUS therapy table, treatment sonication with intraoperative MR thermom
Sponsors
Shiro Horisawa
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) cervical dystonia 2) Age: 20-70 3) Toronto Western SpasmodicTorticollis Rating Scale severity scale more than 15 4) medically and botulinum toxin injection refractory cervical dystonia 5) patient who can understand the study protocol by oneself
Exclusion criteria
Exclusion criteria: 1) inability to stop antiplatelete or anticoagulant medications 2) inability to take MRI 3) lactating or pregnant woman 4) on hemodialysis 5) intractable hypertension ( diastolic pressure > 100) 6) past history of cranial surgery 7) past history of cervical surgery 8) past history of stroke 9) past history of structural lesion in the brain 10) progressive neurodegenerative disease 11) past history of psychiatric disorders 12) Any patient that in the investigator's opinion preclude participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 6-month postoperative Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) | — |
Secondary
| Measure | Time frame |
|---|---|
| BFMDRS, BDI, BAI, AES, MMSE, Postoperative neurological deficit | — |
Contacts
Public ContactHorisawa Shiro
Tokyo Women's Medical University Hospital
Outcome results
None listed