Major depressive disorder Depression
Conditions
Interventions
Photobiomodulation
Sponsors
Kitahata Ryosuke
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Patients diagnosed with major depressive disorder according to DSM-5 diagnostic criteria 2)Patients with mild depression with a MADRS score between 15 and 19 3)Patients who can spend 3 hours wearing research equipment with naked eyes (or contact lenses that meet certain criteria*) 4)Outpatient 5)Men and women aged 20 to 74 at the time of obtaining consent 6)Patients who have written informed consent to participate in this study. * Contact lenses with UV protection and colored contact lenses cannot be used
Exclusion criteria
Exclusion criteria: 1)Patients with cerebral organic diseases (intermediate intracranial organic lesions or neurodegenerative diseases, etc.) 2)Patients with a history of seizures or epilepsy 3)Patients with a psychiatric diagnosis other than depression 4)Patients who are receiving psychotherapy in 1 month prior to the screening 5)Patients who are difficult to participate in this study due to mental instability 6)Patients at high risk of suicide such as suicide intent and attempt 7)Patients with serious or unstable physical illness 8)Patients with severe cataract (nuclear sclerosis grade 3 or higher) 9)Patients who underwent ophthalmic surgery within 6 months before obtaining consent. 10)Patients with retinal abnormalities such as serous retinal detachment and retinal hemorrhage 11)Patients with a history of cancer or patients with serious diseases such as cancer 12)Pregnant or lactating patients 13)Other patients who are judged to be inappropriate by the investigator or the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in MADRS for 4 weeks between the beginning and end of use of the device | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in the following items from the beginning of use of the e device - HAM-D17 - QIDS-J - MoCA-J - PSQI - BSS - Resting-state EEG | — |
Contacts
Public ContactYoshihiro Noda
Keio University Hospital
Outcome results
None listed