Effect of inhalation of hydrogen gas on postoperative recovery

Effect of inhalation of hydrogen gas on posthepatectomy recovery Double-blind randomized controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs032200332

Enrollment

Registered

2021-01-29

Start date

2021-01-29

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatobiliary diseases

Interventions

inhalation of hydrogen gas

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 20 years old and elder (regardless of gender) 2. Patient who undergone hepatic resection for hepatobiliary cancer (regrdless of operative procedure, range of hepatectomy and peimary disease) 3. patient who accept entry to this study with free will after sufficient exposition

Exclusion criteria

Exclusion criteria: 1. Severe liver dysfunction or severe renal dysfunction 2. Uncontrollable diabetes mellitus 3. Pregnancy or possibility of being pregnant 4. Lactating patient 5. Patient who received another test agent or investigational agent within three months prior to agreement for this study 6. Patient who require combined other organ resection (Stomach, Colon, Lung and so on) 7. Patient who required biliary tract reconstruction 8. Patient who required emergency surgery (HCC rupture) 9. Patient who is considered as inadequate by principal investigator of this study

Design outcomes

Primary

Measure	Time frame
QoR40 of postoperative day 3	—

Secondary

Measure	Time frame
1. QoR40 except postoperative day3 2. Postoperative complications (Clavien-Dindo score) 3. Wound pain (NRS) 4. Dietary intake 5. The number of steps taken 6. Inflammatory response (WBC, CRP, neutrophils, lymphocyte, IFN-gamma, IL-6, TNF-arpha) 7. Live functions (T-BIL, AST, ALT, ALP, Albumin, thrombocyte, PT, ICG) 8. Reactive oxygen value (urinary 8-OHdG) 9. adverse event 10. time of inhalation of hydrogen gas	—

Measure

Time frame

1. QoR40 except postoperative day3 2. Postoperative complications (Clavien-Dindo score) 3. Wound pain (NRS) 4. Dietary intake 5. The number of steps taken 6. Inflammatory response (WBC, CRP, neutrophils, lymphocyte, IFN-gamma, IL-6, TNF-arpha) 7. Live functions (T-BIL, AST, ALT, ALP, Albumin, thrombocyte, PT, ICG) 8. Reactive oxygen value (urinary 8-OHdG) 9. adverse event 10. time of inhalation of hydrogen gas

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Contacts

Public ContactHisashi Kosaka

Kansai Medical University

kosakahi@hirakata.kmu.ac.jp+81-72-804-0101

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026