Clinical research to confirm the safety of bone regeneration promoting materials

Clinical research to confirm the safety of bone regeneration promoting materials based on type 1 collagen - Synthetic bone graft substitute transplantation for the socket preservation

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

JPRN

Registry ID

JPRN-jRCTs032200108

Enrollment

Registered

2020-09-07

Start date

2020-09-07

Completion date

Unknown

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Socket preservation

Interventions

Transplant a bone grafting material into the tooth extraction socket

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Patients who perform tooth extraction on the premise of the dental implant treatment

Exclusion criteria

Exclusion criteria: -Active generalized periodontal disease; evident periapical radiolucencies or abscesses -autoimmune disorders; taking or having a history of bisphosphonate medications or Denosumab (history of MRONJ (medication-related osteonecrosis of the jaw)/BRONJ (bisphosphonate-related osteonecrosis of the jaw)) -Current taking methotrexate(MTX) or steroids. -Congenital or metabolic bone disorders; or uncontrolled diabetes. -Current or former smoker or user of chewing tobacco or nicotine-containing products -Females who are pregnant, breastfeeding, or are planning to conceive during their enrollment in the clinical investigation. -History of any severe allergic or anaphylactic reactions to collagen or gelatin, or current sensitivity to collagen or gelatin. -Have a history of complicate malignant tumor.

Design outcomes

Primary

Measure	Time frame
Safety - the Nature and Frequency of Adverse Events	—

Secondary

Measure	Time frame
Safety and Efficacy	—

Contacts

Public Contactkeiko wakana

Juntendo University

kwakana@juntendo.ac.jp+81-3-3818-7815

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026