Breast cancer Breast cancer
Conditions
Interventions
Carbon-ion radiotherapy (C-ion RT) is performed using medical heavy particle accelerator (HIMAC) installed at National Institute of Radiological Sciences. The irradiation range includes the tumor iden
Sponsors
Kobayashi Kana
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Pathologically proven ductal carcinoma in situ or invasive ductal carcinoma (usual type) 2.Single lesion, tumor 2 cm or less on MRI: which is classified as Stage 0-I (UICC) 3.No lymphovascular space involvement, no extensive intraductal carcinoma 4.Luminal A like sub type (in case the patient has IDC) 5.Performance status 0 to 2 6.Age 50 years old and over 7.No other life-threatening illness 8.Written informed consent with
Exclusion criteria
Exclusion criteria: 1.Severe complication 2.Previous treatment 3.Active double primary 4.Tumor invasion to skin or chest wall 5.Distance between tumor border to skin less than 5mm 6.Previous irradiation at tumor site 7.Medically, psychologically or other reason who are not suitable for candidate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In phase I: Acute toxicities of normal tissue Evaluation of dose limitting toxicities In phase II: Preliminary local effect (non-PD rate) | — |
Secondary
| Measure | Time frame |
|---|---|
| In phase I: Adverse reaction of normal tissue in late phase Preliminary local effect (non-PD rate) Breast cosmetic outcomes QOL at 2 years after the treatment In phase II: Adverse reaction of normal tissue in acute phase Adverse reaction of normal tissue in late phase Local control rate at 2 years Breast cosmetic outcomes Progression-free survival period Overall survival period QOL at 2 years after the treatment | — |
Contacts
Public ContactMasaru Wakatsuki
QST Hospital, National Institutes for Quantum Science and Technology
Outcome results
None listed