Dementia, Eye diseases, Brain diseases
Conditions
Interventions
Administer the unapproved PSO17 as eye drops and perform MRI imaging
Sponsors
Miyata Mari
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Individuals aged 18 years or older at the time of consent acquisition 2.Individuals with corrected visual acuity of 0.7 or better in both eyes 3.Individuals who voluntarily apply and are judged by the principal investigator or sub-investigator to be capable of understanding the content of the explanatory document 4.Individuals from whom written consent can be obtained
Exclusion criteria
Exclusion criteria: 1.Individuals with serious medical conditions, or those with such a history whom the physician serving as the investigator deems unsuitable as research subjects 2.Individuals with metallic objects in their body (including tattoos, permanent makeup, pacemakers, etc.) 3.Individuals with severe claustrophobia or fear of the dark 4.Pregnant individuals, those who may be pregnant, and breastfeeding individuals 5.Individuals with a history of severe hypersensitivity to drugs 6.Other individuals deemed it unsuitable as research subjects by the physician serving as the investigator
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visualization of ocular and cerebral dynamics in PSO17 | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in water dynamics between healthy adults and patients with diseases Comparison of 1H-MRI and 17O-MRI imaging data | — |
Contacts
Public ContactMari Miyata
National Institutes for Quantum Science and Technology
Outcome results
None listed