Milk or hens egg allergy Milk allergy, Egg allergy
Conditions
Interventions
Oral intake of 1-Kestose 1 or 2g once a day for 24 weeks
Sponsors
Sugiura Shiro
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1)Infants and children who have been diagnosed with milk or egg allergy in the oral food challenge. 2)Persons who can obtain the consent of parents who fully understand the purpose and content of this test. As much as possible, obtain verbal or written ascents from the research subject. 3)Persons who are between 6 months and 15 years old Japanese at the time of informed consent.
Exclusion criteria
Exclusion criteria: 1)Persons who have chronic illness, receiving medication, have a serious disease history except allergic diseases 2)Persons who are allergic to the test food 3)Persons who have participated in other tests within the first month before the start of the test, or those who intend to participate in another exam after consenting to this exam 4)Persons who ingest probiotic food and prebiotic food on a daily basis (more than 3 times a week)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Results of oral food challenge test conducted at the beginning of the study and after 12 weeks and 24 weeks from the start of intake | — |
Secondary
| Measure | Time frame |
|---|---|
| 1)Milk- or egg-white-specific IgE and IgG4 levels in serum at the start of intake of 1-Kestose and after 12 weeks and 24 weeks from the start of intake 2)EASI score at the start of intake of 1-Kestose and after 6, 12, 18, and 24 weeks from the start of intake 3)Analyze the intestinal flora in feces using the next-generation sequencer at the start of intake of 1-Kestose and after 12 weeks and 24 weeks from the start of intake. 4)Confirm the presence or absence of adverse events during the study period through daily diaries and medical interviews. | — |
Contacts
Public ContactShiro Sugiura
Aichi Children's Health and Medical Center
Outcome results
None listed