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Doxycycline prophylaxis for sexually transmitted infection

The study of doxycycline pre/post exposure prophylaxis for sexually transmitted infection

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
JPRN
Registry ID
JPRN-jRCTs031250679
Enrollment
350
Registered
2026-01-26
Start date
2026-02-19
Completion date
Unknown
Last updated
2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sexuall Transmitted Disease Chlamydia trachomatis, Neisseria gonorrhoeae, Treponema pallidum, Mdoxycycline

Interventions

Vibramycin 200 mg single dose administered 24 hours before to 72 hours after each sexual intercourse. Subjects who have given consent will begin the intervention.Follow-up will be conducted every 3 mo

Sponsors

Mizushima Daisuke
Lead Sponsor

Eligibility

Sex/Gender
Male

Inclusion criteria

Inclusion criteria: The applicant must meet all of the following conditions (1) through (4). (1) Persons aged 18 or older who are attending our sexual health (SH) clinic. (2) Persons with a history of sexually transmitted infections while attending the SH clinic. (3) Those who are on PrEP (pre-exposure prophylaxis) for HIV (4) Persons who have given written consent to participate in the study.

Exclusion criteria

Exclusion criteria: (1) Those who are allergic to any of the study drug. (2) Other cases in which the physician in charge determines that participation in the study is inappropriate.

Design outcomes

Primary

MeasureTime frame
Incidence rate of sexually transmitted infection (gonorrhoea, chlamydia, or syphilis)

Secondary

MeasureTime frame
(1) Incidence rate of each sexually transmitted infection (gonorrhoea, chlamydia, or syphilis) (2) Percentage of adverse events. (3) Adherence to medications. (4) Dosage of doxycycline

Contacts

Public ContactDaisuke Mizushima

Japan Institute for Health Security National Center for Global Health and Medicine

mizushima.d@jihs.go.jp+81-3-3202-7181

Outcome results

None listed

Source: JPRN (via WHO ICTRP) · Data processed: Jul 3, 2026