Normal subjects
Conditions
Interventions
Positron emission tomography study using un-approved ligand [11C]MMP
positron emission tomography, cerebral blood flow
Sponsors
Ishii Kenji
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Subjects who meet all of the following criteria will be included in this study: 1. Male subjects aged 20 to 60 years at the time of consent 2. Subjects who have given written consent to participate in this study
Exclusion criteria
Exclusion criteria: Subjects with any of the following diseases or medical histories will be deemed ineligible at the time of enrollment and excluded. 1. Those with a history of psychiatric and neurological disorders, such as epilepsy, major depression, or schizophrenia. 2. Those who smoke. 3. Those deemed unsuitable for head MRI examination. 4. Those with a history of severe drug hypersensitivity. 5. Those with a history of cardiovascular disease. 6. Those currently suffering from internal medical diseases, such as chronic anemia or chronic renal failure. 7. Other subjects deemed unsuitable by the principal investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of safety associated with administration of [11C]MMP Pharmacokinetics of [11C]MMP (metabolism, blood clearance, urinary excretion rate) Evaluation of internal radiation dose associated with administration of [11C]MMP | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Optimizing the method and timing of image acquisition 2. Establishing a quantitative method (calculating the brain [11C]MMP transfer rate constant and distribution volume) 3. Establishing an image evaluation and analysis method (comparison of brain [11C]MMP distribution, pharmacokinetic parameters, [15O]H2O distribution, and regional cerebral blood flow) | — |
Contacts
Public ContactMami Yoshioka
Tokyo Metropolitan Institute for Geriatrics and Gerontology
Outcome results
None listed